Λέκκα Μαρία-Ελένη
Department of Chemistry
Contact Information
Phone: +30-26510 08367
FAX: +30-26510 08774
E-mail: mlekka@uoi.gr
DEGREES
Degree: Ph.D.
Year: 1987
Institution:
University of Ioannina, Department of Chemistry
Degree: B.Sc.
Year: 1977
Institution: University of Thessaloniki, Department of Chemistry
Research Interests
- Chemical characterisation and biological evaluation of bioactive natural products
- Lipid chemistry, biochemistry and signalling
- Lung inflammation and the role of phospholipase A2 isoforms
- Phospholipases, regulation of expression
The role of extracellular vesicles in the dissemination of inflammation
Professional background
| 2022 – today
2022 – 2011 1993 – 2002 2002 – 2011 1989 – 1993 1980 - 1989 1979 - 1980 |
Emeritus Professor
Professor, Dept. of Chemistry, UoI Assoc. Professor, Dept. of Chemistry, UoI Assist. Professor, Dept. of Chemistry, UoI Lecturer, Dept. of Chemistry, UoI Scientific Associate, Dept. of Chemistry, UoI Koropoulis AE, Industry of raw materials |
- 1996,1998,2001 Invited Professor University Victor Segalen, Bordeaux-2, Lab of Membrane Biogenesis. Teaching in undergraduate and graduate programmes
Post-doctoral research experience:
- Physiology Dept. of Kuopio, Finland, (1995). «Biotransformation of xenobiotics». Research Fellow
- of Biochemistry, University of Texas at San Antonio, Health Science Center, (1989-1990). «Molecular characterization of platelet-activating factor inhibitors». Research Fellow
- INSERM U 200, Paris-France. «Biosynthetic enzymes of PAF» (1988)
- University Victor Segalen, Bordeaux-2, Lab. of Membrane Biogenesis (1998) “Lipid autoantibodies in bronchoalveolar lavage fluid”
Selected publications/patents
Dr M.E. Lekka has published 72 publications (scopus), one patent and has been involved in more than 20 research projects.
Patent
Lekka ME, Karkabounas A, Res Committee – University of Ioannina (2011) «Immobilisation of lipid substrates for the development and evaluation of a fluorimetric assay of phospholipase A2 in biological fluids” INDUSTRIAL PROPERTY ORGANIZATION, GR1007801.
Selected publications
| Dr M.E. Lekka has published 72 publications (scopus), one patent and has been involved in more than 20 research projects.
Patent Lekka ME, Karkabounas A, Res Committee – University of Ioannina (2011) «Immobilisation of lipid substrates for the development and evaluation of a fluorimetric assay of phospholipase A2 in biological fluids” INDUSTRIAL PROPERTY ORGANIZATION, GR1007801. Selected publications 1. Karkabounas A, Georgiadou DG, Argitis P, Psycharis V, Nakos G, Kosmas AM, Lekka ME. (2015) “Immobilization of Lipid Substrates: Application on Phospholipase A2 Determination”. Lipids. 50(12):1259-1271. doi: 10.1007/s11745-015-4076-y. 2. Yfanti P, Batistatou A, Manos G, Lekka ME (2015) “The Aromatic Plant Satureja horvatii ssp. macrophylla Induces Apoptosis and Cell Death to the A549 Cancer Cell Line” Am J Plant Sci 6:2092-2103 doi: 10.4236/ajps.2015.613210. 3. Fais S, et al. (2016) “Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine”. ACS Nano. 10(4):3886-3899. doi: 10.1021/acsnano.5b08015. 4. Vlaikou AM, Kouroupis D, Sgourou A, Markopoulos GS, Bagli E, Markou M, Papadopoulou Z, Fotsis T, Nakos G, Lekka ME, Syrrou M (2017) “Mechanical stress affects methylation pattern of GNAS isoforms and osteogenic differentiation of hAT-MSCs”. Biochim Biophys Acta: Mol Cell Res. 1864(8):1371-1381. doi:10.1016/j.bbamcr.2017.05.005. 5. Vasdekis EP, Karkabounas A, Giannakopoulos I, Savvas D, Lekka ME (2017) Screening of mushrooms bioactivity: piceatannol was identified as a bioactive ingredient in the order Cantharellales. Eur Food Res Technol, 244(5), 861-871 DOI:10.1007/s00217-017-3007-y 6. Tzounakas VL, Karadimas DG, Anastasiadi AT, Georgatzakou HT, Kazepidou E, Moschovas D, Velentzas AD, Kriebardis AG, Zafeiropoulos N, Avgeropoulos A, Lekka M, Stamoulis KE, Papassideri IS, Antonelou MH (2018) Donor-specific individuality of red blood cell performance during storage is partly a function of serum uric acid levels. Transfusion 58(1):34-40. doi: 10.1111/trf.14379. 7. Moustaka K, Maleskou E, Lambrianidou A, Papadopoulos S, Lekka ME, Trangas T and Kitsiouli E (2019) Docosahexaenoic Acid Inhibits Proliferation of EoL-1Leukemia Cells and Induces Cell Cycle Arrest and Cell Differentiation. Nutrients, 11(3), 574- , https://doi.org/10.3390/nu11030574, https://www.mdpi.com/2072-6643/11/3/574 8. Yfanti P, Karkabounas A, Batistatou A, Tsapinou A, Leneti E, Manos G, Marilena E. Lekka ME (2020) Study of potent cytotoxic activity of Helleborus cyclophyllus Boiss against a human adenocarcinoma cell line. Cytotechnology. https://doi.org/10.1007/s10616-020-00425-4. 9. Papadopoulos S, Kazepidou E, Antonelou MH, Leondaritis G, Tsapinou A, Koulouras VP, Avgeropoulos A, George Nakos G, and Lekka ME (2020). Secretory phospholipase A2-IIA protein and mRNA pools in extracellular vesicles of bronchoalveolar lavage fluid from patients with early acute respiratory distress syndrome: A new perception in the dissemination of inflammation? Pharmaceuticals (Basel). 2020, 13(11):415. doi: 10.3390/ph13110415. 10. Scieuzo C, Giglio F, Rinaldi R, Lekka ME, Cozzolino F, Monaco V, Monti M, Salvia R, Falabella P. In Vitro Evaluation of the Antibacterial Activity of the Peptide Fractions Extracted from the Hemolymph of Hermetia illucens (Diptera: Stratiomyidae). Insects. 2023 May 15;14(5):464. Selected Research projects / grants
Region of Epirus (2021): (MIS) 5047235 «ΕΥ-AGRI-FOOD)» & “BIOMED-20” |
